David W Walker Selected Research

Pregnanolone (Allopregnanolone)

5/2017	Increased anxiety-like phenotype in female guinea pigs following reduced neurosteroid exposure in utero.
1/2017	Cerebellar Changes in Guinea Pig Offspring Following Suppression of Neurosteroid Synthesis During Late Gestation.
1/2016	Loss of neurosteroid-mediated protection following stress during fetal life.
1/2012	Effect of maternal administration of allopregnanolone before birth asphyxia on neonatal hippocampal function in the spiny mouse.
3/2011	Sex-dependent effect of a low neurosteroid environment and intrauterine growth restriction on foetal guinea pig brain development.
1/2011	Neuroactive steroids induce changes in fetal sheep behavior during normoxic and asphyxic states.
3/2008	Neurosteroids in the fetus and neonate: potential protective role in compromised pregnancies.
1/2008	Brain allopregnanolone in the fetal and postnatal rat in response to uteroplacental insufficiency.
1/2006	Stress in pregnancy activates neurosteroid production in the fetal brain.
1/2006	Hypoxia potentiates endotoxin-induced allopregnanolone concentrations in the newborn brain.

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David W Walker Research Topics

Disease

29	Hypoxia (Hypoxemia) 01/2022 - 03/2005
18	Asphyxia (Suffocation) 01/2019 - 10/2004
14	Brain Injuries (Brain Injury) 01/2022 - 01/2006
10	Fetal Growth Retardation (Intrauterine Growth Retardation) 06/2019 - 12/2009
9	Premature Birth (Birth, Premature) 01/2018 - 01/2009
8	Inflammation (Inflammations) 01/2022 - 01/2006
6	Body Weight (Weight, Body) 07/2021 - 06/2014
5	Infections 10/2013 - 01/2005
4	Mitochondrial Diseases (Mitochondrial Disease) 01/2022 - 07/2004
4	Fetal Hypoxia 01/2022 - 04/2008
4	Placental Insufficiency 06/2019 - 12/2003
4	Ischemia 11/2018 - 06/2005
3	Acidosis 01/2021 - 01/2012
3	Neurodegenerative Diseases (Neurodegenerative Disease) 05/2013 - 05/2008
2	Brain Diseases (Brain Disorder) 10/2021 - 01/2013
2	Hypercapnia 01/2021 - 01/2012
2	Fetal Weight 01/2021 - 08/2008
2	Birth Weight (Birth Weights) 01/2020 - 01/2019
2	Pre-Eclampsia (Preeclampsia) 01/2020 - 01/2016
2	Neoplasms (Cancer) 01/2020 - 08/2017
2	Stroke (Strokes) 01/2019 - 04/2006
2	Schizophrenia (Dementia Praecox) 01/2019 - 04/2006
2	Gliosis 01/2018 - 01/2012
2	Brain Hypoxia-Ischemia (Hypoxia Ischemia, Brain) 01/2017 - 05/2016
2	Cerebral Palsy (Spastic Diplegia) 01/2017 - 12/2014
2	Hypothermia 01/2017 - 05/2016
2	Traumatic Brain Injuries (Traumatic Brain Injury) 05/2015 - 03/2011
2	Necrosis 01/2014 - 01/2006
2	Alzheimer Disease (Alzheimer's Disease) 02/2012 - 04/2006
2	Single Umbilical Artery 01/2012 - 03/2007
2	Nervous System Diseases (Neurological Disorders) 05/2008 - 04/2006
2	Hyperoxia 05/2008 - 07/2004
2	Sudden Infant Death (SID) 01/2006 - 12/2002
1	Hypotension (Low Blood Pressure) 01/2022
1	Chorioamnionitis 01/2022
1	Fetal Death 01/2019
1	Dysbiosis 11/2018
1	Neuroinflammatory Diseases 01/2018
1	Brain Hypoxia (Cerebral Hypoxia) 01/2018
1	Anxiety Disorders (Anxiety Disorder) 05/2017
1	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 05/2017
1	Wounds and Injuries (Trauma) 04/2017
1	Acute Kidney Injury (Acute Renal Failure) 04/2017
1	Chronic Renal Insufficiency 04/2017
1	Seizures (Absence Seizure) 01/2017
1	Epilepsy (Aura) 01/2017
1	Fatigue 01/2016
1	Weight Gain 01/2016
1	Fragile X Syndrome (Martin Bell Syndrome) 01/2016
1	Vitamin D Deficiency 01/2016

Drug/Important Bio-Agent (IBA)

19	CreatineIBA 01/2022 - 04/2008
12	Pregnanolone (Allopregnanolone)IBA 05/2017 - 12/2002
10	NeurosteroidsIBA 01/2017 - 10/2004
8	Oxygen (Dioxygen)IBA 01/2022 - 07/2004
6	EnzymesIBA 01/2019 - 12/2003
6	SteroidsIBA 01/2012 - 01/2006
5	Proteins (Proteins, Gene)FDA Link 11/2018 - 04/2006
4	LipopolysaccharidesIBA 01/2022 - 01/2005
4	salicylhydroxamic acid (SHAM)IBA 01/2021 - 03/2005
4	Messenger RNA (mRNA)IBA 01/2020 - 11/2010
4	MelatoninIBA 04/2014 - 03/2005
4	EndotoxinsIBA 01/2008 - 01/2005
3	hydroxide ionIBA 01/2022 - 03/2005
3	Dopamine (Intropin)FDA LinkGeneric 01/2022 - 11/2018
3	Hydrocortisone (Cortisol)FDA LinkGeneric 01/2021 - 01/2006
3	Dobutamine FDA LinkGeneric 01/2021 - 01/2018
3	Tryptophan (L-Tryptophan)FDA Link 01/2017 - 01/2005
3	KynurenineIBA 01/2017 - 01/2005
3	Ethanol (Ethyl Alcohol)IBA 06/2014 - 03/2005
3	CytokinesIBA 01/2014 - 01/2006
3	GlucocorticoidsIBA 10/2013 - 12/2009
2	LeptinIBA 07/2021 - 12/2020
2	Serotonin (5 Hydroxytryptamine)IBA 06/2019 - 01/2019
2	Quinolinic AcidIBA 05/2015 - 01/2005
2	Caspase 3 (Caspase-3)IBA 01/2009 - 01/2007
2	Apolipoproteins D (Apo D)IBA 05/2008 - 04/2006
2	Reactive Oxygen Species (Oxygen Radicals)IBA 06/2005 - 07/2004
1	Adenosine Triphosphate (ATP)IBA 01/2022
1	Pharmaceutical PreparationsIBA 01/2020
1	Polo-Like Kinase 1IBA 01/2020
1	MidkineIBA 01/2020
1	3K3A-APC proteinIBA 01/2019
1	Amino Acids FDA Link 01/2019
1	Creatine Kinase (Creatine Phosphokinase)IBA 01/2019
1	Dehydroepiandrosterone (DHEA)IBA 01/2019
1	Protein CIBA 01/2019
1	Adrenergic Agonists (Adrenergic Receptor Agonist)IBA 11/2018
1	Adrenergic Receptors (Adrenergic Receptor)IBA 11/2018
1	CollagenIBA 04/2017
1	ganaxoloneIBA 01/2017
1	SodiumIBA 01/2016
1	ElectrolytesIBA 01/2016
1	Calcitriol Receptors (Calcitriol Receptor)IBA 01/2016
1	ChloridesIBA 01/2016
1	Vitamin D FDA LinkGeneric 01/2016
1	70-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)IBA 01/2016

Therapy/Procedure

10	Therapeutics 01/2020 - 04/2008
5	Cesarean Section (Caesarean Section) 01/2016 - 01/2009
2	Ligation 01/2012 - 03/2007
1	Infant Equipment (Crib) 01/2019